Reducing Unrelieved Pain and Distress in Laboratory Animals Using Humane Endpoints

Pain management and humane endpoints.

Unrelieved pain and distress in animals: an analysis of USDA data on experimental procedures.

Pain and distress are core issues in the field of animal experimentation and in the controversy that surrounds it. We sought to add to the empirical base of the literature on pain and distress by examining government data on experimental procedures that caused unrelieved pain and distress (UPAD) in animals. Of the species regulated by the U.S. Department of Agriculture (USDA), most of the appro...

Studying humane endpoints in a rat model of mammary carcinogenesis

Objective(s): The present work intended to clearly define the most adequate humane endpoints in an experimental assay of mammary carcinogenesis in rats. Materials and Methods: Animals were observed twice a day; all parameters were registered once a week and the euthanasia endpoints were established in order to monitor the animal welfare/...

Humane Slaughtering of Animals

To the Editor of The Hospital and Health Review. Sir,?There are few questions at present before the public which can compare in importance with that of slaughterhouse reform. There is the cruelty of killing animals by old-fashioned and inefficient methods, there is the insanitary condition of the slaughterhouse and consequent contamination of the meat, there is thewholesale poisoning of the mea...

Humane endpoints for infectious disease animal models.

Since the work of pioneers such as Jenner and Pasteur (Fenner et al. 1997) more than a century ago, animal models have provided essential information in the study of infectious diseases. Although much experimentation can now be accomplished with in vitro systems, animals continue to be necessary for this field for studying the process of inflammation, specific infectious diseases, and pharmacol...